Synapses are points of connections between neurons where information is transmitted, and memories formed. The brain, especially as we get old, can be subject to different neurodegenerative diseases, leading to cognitive and/or motor disorders depending on the area and type of neurons affected. During neurodegeneration, synapses are also affected, either directly by pathological processes, or as a consequence of neuronal loss. The mechanisms leading to synaptic dysfunction and loss are not completely understood, yet, and great efforts are made trying to unravel them.

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