Black people have the highest cancer mortality rate of any racial or ethnic group. Among Black women, breast cancer makes up about a third of all cancer diagnoses, with ER+ breast cancer being the most common. Black women with ER+ breast cancer are 42% more likely to die of the disease than white women.
This study examined gene expression in breast tumor and normal samples from 185 Black patients and compared them to samples from white women, revealing significant molecular differences in DNA repair in breast tissue that could help explain why more Black women die from ER+ breast cancer. The work suggests that addressing the disparity could be as simple as changing the timing of existing breast cancer treatments for Black women.
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