Prostate cancer is the most common malignancy among men in the United States and Canada. Traditional factors such as cancer extent (stage) and differentiation grade are employed to assess prostate cancer prognosis, but they lack accuracy. In this study recently published in International Journal of Surgical Pathology, we highlight additional risk factors in prostate cancer: the sieve-like shape of the cancer under the microscope (cribriform pattern) and the number of the cancerous foci within the vascular spaces. We hope to increase men’s awareness of prostate cancer and to provide clinicians with valuable measures to consider when treating their patients.